The presumption that LDL cholesterol should be lowered because genetically low cholesterol individuals do not develop heart disease is flawed.

“So there is a presumption that because they had people with genetically low cholesterol who had low cholesterol didn't have heart disease we should lower it and that that that doesn't make any sense because you know this Mendelian randomization we talk about means there could be other genes and probably are associated with low cholesterol that actually are the driving force between not developing heart disease and longevity but it's actually nothing to do with the low cholesterol itself.”