David Sinclair· PhD
In many ways, this aligns with the Information Theory of Aging, which proposes that cells lose epigenetic information over time but retain a backup copy that can potentially be restored.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In many ways, this aligns with the Information Theory of Aging, which proposes that cells lose epigenetic information over time but retain a backup copy that can potentially be restored.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Over the past two decades, however, a different idea has emerged: that aging may involve changes to the epigenome, the regulatory information layered on top of DNA If those changes can be reversed, cells might recover youthful function without changing their identity.
but what I think exists in cells we have some evidence is that like Shannon suggested for the internet or information is it if you have a backup copy and now going back to the genome there seems to be something in cells that tells them these methyl groups the program that was laid down when you're a baby is still there and cells can access that somehow to say all these other things that have happened since you're born or since you're a teenager that's just noise that's crap ignore that
ultimately if you're a thousand years old you may have lost a lot of the genetic information but epigenetic information because there's this backup Drive this observer that we have found exists in cells somehow that you can tap into as long as the genome that DNA strands are still largely intact we can reverse aging but it's an information loss issue
but what warps my mind it blows my mind is that there is something in the cell that we've had all along in our lives that allows the cell to reset
are you suggesting that at least to the first order if you restored the methylation status to what it looked like when you were born you'd have a younger phenotype