David Sinclair· PhD
The sirtuins will get activated by these, what we call hormetic effects. What doesn't kill them, makes them stronger.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The sirtuins will get activated by these, what we call hormetic effects. What doesn't kill them, makes them stronger.
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sirtuins both in yeast and mammals were not only necessary but were sufficient when you ever expressed them to mimic calorie restriction
this was through a process of mimicking calorie restriction. If you have a lot of sirtuins, you get the benefits of calorie restriction or dieting and other types of little stresses on the cell like heat and a bit of a lack of amino acids.