Andrew Huberman· PhD
4) Dosage needs vary *enormously*
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
4) Dosage needs vary *enormously*
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
he made very clear that it is extremely extremely difficult to predict how a child or adult will react to a given dosage of any of these drugs so much so in fact that he anecdotally reported to me that one of his patients is a male 3 100 pounds diagnosed with ADHD and who achieves tremendous relief from just 2.5 milligrams of Adderall per day and at the same time he has two patients both of whom are sisters so they're genetically related who are in the 120 to 140 pound range who did not respond well at all for the treatment of their ADHD until their dosages were very very high
one of his patients is a male 3 100 pounds diagnosed with ADHD and who achieves tremendous relief from just 2.5 milligrams of Adderall per day and at the same time he has two patients both of whom are sisters so they're genetically related who are in the 120 to 140 pound range who did not respond well at all for the treatment of their ADHD until their dosages were very very high and if I tell you these dosages I just want to warn you in advance I'm not suggesting anyone explore these dosages without of course the approval of their psychiatrist turns out that neither of these two young women responded at all to ADHD medication until they achieved dosages in the range of 180 in the case of one sister and 240 milligrams in the case of the other sister per day