CRISPR technology offers improved site specificity and high fidelity for genetic modifications, allowing for increased titer and penetrance of engineered DNA without increasing off-target effects.

“CRISPR on the other hand, started out being pretty good at its site specificity. And better than that, as time's gone on, very rapid advances have been made such that now, it's just out of site site-specific. It's incredibly high fidelity. That means that one can increase the titer, the amount of engineered DNA that you stick into their body that's supposed to go and modify cells. And by increasing the titer, you can increase the penetrance, the proportion of cells that are actually modified in the way you want, without increasing the off-target effects, because the off-target effects are being eliminated by the nature of CRISPR.”