Melatonin may make pancreatic islet cells less responsive to glucose, leading to reduced insulin production and release, which can cause elevated blood sugar levels.

“And this engagement of melatonin with the pancreas receptor essentially tells the pancreas, "Okay, it's time to sleep, you don't have to bother releasing insulin."”

“melatonin is actually what is responsible for shutting down the pancreatic beta cells from producing insulin.”

“if our circadian conditions are optimal meaning we aren't bathing ourselves in bright blue light before bed our bodies naturally start to produce melatonin around 2 to 3 hours before we go to sleep melatonin has been shown to bind to receptors on the pancreas and this signals to the pancreas to stop producing insulin that means that our blood glucose levels will remain elevated because glucose is not getting taken up into our cells”

“we know that in the evening as our body prepares to sleep a melatonin level begins to rise and that melatonin usually rises 2 to 3 hours before our habitual sleep time so if somebody is going to bed around 11:00 then that melatonin is beginning to rise around nine o'clock on an average for some people it might rise around four hours early and some people it will rise exactly at bedtime and when melatonin rises there is new data showing that melatonin can bind to its receptor in pancreas and this and gasma and melatonin with the pancreas receptor essentially tells differently as okay it's time to sleep Don you don't have to bother releasing insulin so in that way what happens if somebody is having a big meal when there is high melatonin and that may not be enough insulin released from pancreas and glucose may stay high in the blood circulation for a long time”

“That means it makes our pancreas to sleep, or islet cells to sleep. That means it makes these Insulin-producing cells less responsive to glucose so that they don't produce as much insulin as they should when we eat something that has carbohydrate or glucose.”

“And now, we are coming to understand at least part of it is due to melatonin.”

“you have previously said in another podcast, you've talked about how melatonin actually can inhibit the secretion of insulin from the beta cells in the pancreas, the islet cells in the pancreas, and that would obviously affect your blood glucose levels.”

“it's a good rule of thumb to make sure that you have finished your last meal you finished eating before that time so you know before three three hours before your natural bedtime”

“we have melatonin receptors on our pancreas on our pancreatic beta eyelid cells and the Melatonin receptors the 1B receptors are sensitive to melatonin”