Andrew Huberman· PhD
So melatonin essentially tells the brain and the body when it's day and when it's night and with that when it's time to sleep, when it's time to wake, but it doesn't really help with the generation of sleep itself.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So melatonin essentially tells the brain and the body when it's day and when it's night and with that when it's time to sleep, when it's time to wake, but it doesn't really help with the generation of sleep itself.
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And then melatonin, we think of that as a sleepiness hormone, but it has fairly weak soporific activity, which means it's not a very strong stimulator for sleep, but it's more of a reinforcer that it is in fact dark out. And so it's telling all the clocks within the suprachiasmatic nucleus, "Yeah, it's now nighttime. Do nighttime activities." So it will affect the transcription and the translation activity that's happening.