We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
I personally do not recommend supplementing melatonin because it's supplemented typically at very high levels. One to three milligrams or even more that is an outrageously high dose. It's super, super physiological compared to what you normally would make. It also has a number of potentially negative effects on the reproductive access and hormones there. ... it can reduce the output of the adrenals to the point where it can become problematic.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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It interacts with the reproductive hormones, testosterone and estrogen, and that whole access in ways that are unattractive, at least to me. It suppresses puberty during development. It's present in much, much higher doses in most supplements than one would normally make like a hundred fold, 300 fold.
I'm just concerned about taking high levels of a hormone that has effects on the reproductive axis and that's one of the reasons why I get very concerned when I see people really getting aggressive about melatonin supplementation taking 100, 10, 500, sometimes even 10,000 times the amount that we would normally release.
I personally do not recommend supplementing melatonin because it's supplemented typically at very high levels you know 1 to 3 milligrams or even more that is an outrageous iously high doses also has a number of potentially negative effects on the reproductive axis and and hormones there