The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
That said, it is true that for people that tend to have lower baseline levels of, for instance, dopamine, their levels of happiness, or we should say their self-reported levels of happiness, tend to be lower than for those that have greatly elevated baseline levels of dopamine.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
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Those individuals do tend to be more depressed. They tend to have lower affect. They are less happy. At least, that's how they report themselves to be emotionally.
But when levels of dopamine and serotonin tend to be chronically low for an individual below their typical baseline, they will, yes, tend to be lower in affect and have lower mood and less episodes of happiness per day, per week, per month, per year, et cetera.
But, and it's a very important, but when levels of dopamine and serotonin tend to be chronically low for an individual below their typical baseline, they will, yes, tend to be lower in affect and