Andrew Huberman· PhD
MDMA while it increases dopamine most dramatically increases serotonin like 7x or more
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
MDMA while it increases dopamine most dramatically increases serotonin like 7x or more
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
And my understanding is that MDMA leads to very robust increases in both dopamine and serotonin simultaneously. So why would it be that having this uh increased dopamine and increased serotonin would provide an experience that is beneficial?
MDMA is a unique compound in that it leads to very large increases in the amount of both dopamine and serotonin in the brain and body simultaneously.