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Rapamycin extends mouse lifespan 9–14%
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Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Erasing Fears & Traumas Using Modern Neuroscience | Huberman Lab Essentials — Whalespan

Content›Video›Erasing Fears & Traumas Usin…

Erasing Fears & Traumas Using Modern Neuroscience | Huberman Lab Essentials

Andrew Huberman35m · 2025-11-06

Claims Made

54

Claims Supported

35

Support Rate

65%

Support rate

35 of 54 claims supported

35 supported19 partial / not

Claims from this content

40

✓Well SupportedEffective treatment for fear and trauma requires relearning new narratives and wiring in positive associations with previously feared activities.✓Well SupportedPerforming 25 repetitions of cyclic hyperventilation increases alertness and body warmth by raising epinephrine and adrenaline.✓Well SupportedCortisol and epinephrine are released upon waking to increase heart rate, tense muscles, and prepare for activity.◐Partially SupportedThe HPA axis comprises the hypothalamus, pituitary, and adrenals and uses the brain to alert and prepare the body for action.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

The balance between the sympathetic and parasympathetic nervous systems dictates emotional state and alertness.

◐Partially SupportedKetamine-assisted psychotherapy can reduce emotional experience during trauma recall by inducing dissociation.

◐Partially SupportedMDMA leads to robust increases in dopamine and serotonin.

✓Well SupportedThe hpa axis regulates stress hormones like cortisol and adrenaline.

◐Partially SupportedInositol can decrease anxiety symptoms with potency comparable to prescription antidepressants.

◐Partially SupportedThe anxiety and physiological response to recounting traumatic events progressively diminishes with each subsequent retelling.

◐Partially SupportedKetamine assisted psychotherapy appears to be beneficial for individuals with trauma coupled with depressive symptoms.

◐Partially SupportedThe amygdala can activate the dopamine system responsible for motivation and reward.

◐Partially SupportedThe prefrontal cortex is involved in top-down processing, allowing the brain to control or suppress reflexes by attaching narrative, meaning, and purpose to responses.

◐Partially SupportedAnxiety is often defined as stress about a future event, and while it can be related to fear, anxiety can exist without fear.

◐Partially SupportedSaffron has anxiolytic effects.

◐Partially SupportedEngaging in regular, trusting social connection is beneficial for processing fear and trauma.

◐Partially SupportedTrauma is defined as a fear experience embedded in the nervous system, leading to maladaptive fear responses.

◐Partially SupportedReplacing a fearful or traumatic memory/response with a positive one is required to extinguish the fear or trauma.

◐Partially SupportedDetailed recounting of traumatic and fearful events is essential for the positive effects of prolonged exposure, cognitive processing, and cognitive behavioral therapy.

◐Partially SupportedDeliberate self-directed entry into short bouts of stress, such as cyclic hyperventilation, is a promising approach for managing fear and trauma.

◐Partially SupportedProlonged exposure therapy, cognitive processing therapy, and CBT reduce fears and traumas.

◐Partially SupportedThe hypothalamus can trigger or prevent the release of cortisol and hormones that stimulate adrenal production of adrenaline.

◐Partially SupportedKetamine-assisted psychotherapy and MDMA are emerging as potential drug treatments for PTSD.

◐Partially SupportedPavlovian conditioning is a mechanism by which fear systems learn and anticipate problems.

◐Partially SupportedMDMA assisted therapy may facilitate rapid relearning of new associations onto previously traumatic experiences.

◐Partially SupportedFear is an adaptive response that helps prevent injury, death, and poor decision-making by activating the threat reflex and enabling anticipation of future dangers.

◐Partially SupportedThe human fear system can learn associations from a single event involving the amygdala and threat reflex circuits.

◐Partially SupportedSome fear-evoking memories are protective, while others are dangerous as they limit behavior maladaptively.

◐Partially SupportedThe fear system is largely a memory system designed to embed memories of past experiences to activate the threat reflex in anticipation of future events.

◐Partially SupportedThe longer-lasting component of HPA axis chemicals can feedback to the brain, control gene expression, and build new circuits and chemicals that embed fear.

◐Partially SupportedInositol should not be taken during or prior to therapy sessions aimed at amplifying experience intensity, but can be used outside sessions to help return the system to baseline.

✕Not SupportedIndividuals with anxiety or panic disorders should avoid deliberate self-directed stress induction practices like cyclic hyperventilation.

◐Partially SupportedThe pituitary gland releases hormones into the bloodstream, triggered by the hypothalamus.

◐Partially SupportedThe amygdaloid complex integrates information from memory and sensory systems to generate threat reflexes.

◐Partially SupportedThe amygdala is part of the threat reflex and is the final common pathway through which the threat reflex flows.

◐Partially SupportedThe hypothalamus controls basic functions like temperature, appetite, and thirst, and influences the release of hormones.

◐Partially SupportedThe HPA axis has fast and longer-lasting chemical components that can feedback to the brain, explaining long-lasting fear responses.

◐Partially SupportedFear responses can be managed by attaching narrative, meaning, and purpose to them.

◐Partially SupportedMDMA, also known as ecstasy or Molly, is a synthetic drug that induces a unique chemical state in the brain and body.

◐Partially SupportedNeuroscience has advanced in understanding neural circuits controlling the fear response and methods to extinguish fears.