Ketamine-assisted psychotherapy can reduce emotional experience during trauma recall by inducing dissociation.

“So it's a remapping of new onto old. New meaning new feelings onto old feelings while staying in the exact same narrative. So it's a little bit like EMDR of suppressing the threat reflex but it seems to bring in a replacement of previous emotional experiences and sensations in the body with new ones. And so in that way we can sort of view or we can try and view Ketamine-Assisted Psychotherapy for the treatment of trauma as bringing together the three elements that we talked about before. You want to diminish the intensity, the potency of the old original trauma experience or fear experience. So that seems to be accomplished through this dissociation and maybe through the kind of anesthetic component. So it's a reduction in pain in the body, a dissociation, a kind of observing of the self that leads to the extinction of the trauma and the fear. But then there also seems to be an automatic or kind of built in a relearning of a new narrative, a new set of experiences which is the next step that we described earlier.”