Andrew Huberman· PhD
metabolism metabolic regulation mitochondrial function mitochondrial Health actually is an umbrella concept for everything you've just said it's an umbrella concept for well how do we create neurotransmitters where do these neurotransmitters come from what regulates their production release from cells and then even to go further what impact do those neurotransmitters have on other cells they are largely regulating brain metabolism and the way we usually think about it is they are regulating brain activity but if you ask the question well what is brain activity brain activity is either is fueled by metabolism that a a neuron cannot be active unless it has the capacity to increase its ATP kind of production and then when you suppress a neuron when you inhibit its function the TP production goes down so whether you want to think of metabolism as just a consequence of neural activity I actually think about it as an integral part of neural activity it's kind of like your car can't go without the engine a cell can't go without mitochondria um a cell can't do what it's supposed to do without mitochondria the other concept that you mentioned neuroplasticity neuroplasticity is all about energy and met metabolic resources to create new connections new neural connections between axons dendrites Somas other other aspects of neurons and cells and other types of cells asites oligodendrocytes um but in order to get neuroplasticity neuroplasticity implies growth and modulation and even pruning but it involves change and in order for an living organism to change that requires this foundational concept of metabolism