Paul Saladino· MD
what's happening is that the muscles start to go into glucose refusal mode and they really only want fat and they really only want ketones because that's what it's now learned is the only fuel source coming in
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
what's happening is that the muscles start to go into glucose refusal mode and they really only want fat and they really only want ketones because that's what it's now learned is the only fuel source coming in
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when you are in ketosis when you are using beta oxidation when you are shuttling fatty acids non-esterified fatty acids which are in your blood through the mitochondria through carnitine pulmonary oil transferase through beta oxidation you are in ketosis a lot of the time and that process is going to create physiologic insulin resistance at the level of the muscle