Are There Possible Downsides To A Long Term Ketogenic Diet?

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Paul Saladino5m · 2020-06-08

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Not SupportedCompletely removing glucose (carbohydrates) from the diet can lead to metabolic inflexibility.Partially SupportedWhen in ketosis and utilizing beta-oxidation, the body creates physiological insulin resistance at the muscle level, sparing glucose for essential tissues.Not SupportedProlonged ketogenic diets can lead to physiological insulin resistance with increased fasting glucose levels.Partially SupportedThe body compensates for physiological insulin resistance by increasing endogenous glucose production from the liver.Partially Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Reintroducing carbohydrates to metabolically inflexible individuals may initially cause glucose spikes but can decrease fasting glucose within weeks with consistent reintroduction.

Partially SupportedTemporary insulin resistance from very low-carbohydrate diets can be reversed within approximately three days of reintroducing 100-150 grams of carbohydrates daily.

Partially SupportedLong-term carbohydrate absence may be evolutionarily inconsistent with human physiology, potentially causing metabolic inflexibility.

Partially SupportedResearch associating high fasting glucose with adverse health outcomes may not control for insulin levels, potentially confounding fasting glucose as a sole risk factor.

Partially SupportedIndividuals on very low-carbohydrate diets may be misdiagnosed with diabetes during an oral glucose tolerance test due to a shocked system response to glucose intake.

Partially SupportedPhysiological insulin resistance, characterized by elevated fasting glucose, is distinct from pathological insulin resistance seen in diabetes.