The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
you've got sort of this foundation of metabolic disease so that's everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes that creates the foundation upon which three other disease processes get a lot worse cardiovascular and cerebrovascular disease cancer and neurodegenerative disease
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and then these slew of metabolic diseases that while directly not responsible for an enormous number of lives lost compared to the other categories um indirectly contribute immensely by amplifying all of these
their their real danger of them is the effect that they're having on the other three Horsemen where they're increasing your risk by you know 25 to 50%
their their real danger of them is the effect that they're having on the other three Horsemen where they're increasing your risk by you know 25 to 50%
and then these slew of metabolic diseases that while directly not responsible for an enormous number of lives lost compared to the other categories uh indirectly contri immensely by amplifying all of these
and I refer to it as you know sort of metabolic disease spanning the Spectrum from hyperinsulinemia to insulin resistance to fatty liver disease all the way out to type 2 diabetes um so given how much I speak about that it seems very important that we should have a really uh thorough discussion of that foundational metabolic disease
the fourth horsemen is kind of a spectrum of diseases that we call metabolic diseases um the the most extreme version of this would be type 2 diabetes um but of course all along the way you have conditions like fatty liver disease and insulin resistance and all of these conditions form a continuum and the most important thing to know about them is while not that many people will die directly from those diseases if you have anything along that continuum it's increasing your risk of about by about 50% of the other three horsemen