Andrew Huberman· PhD
leptin signaling is disrupted and there are all sorts of changes on both the brain side and the body end of things, such that they're hungry, despite the fact that the body has plenty of energy on reserve.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
leptin signaling is disrupted and there are all sorts of changes on both the brain side and the body end of things, such that they're hungry, despite the fact that the body has plenty of energy on reserve.
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So, you might ask why is it that people who are overweight and have a lot of body fat, why they would continue to eat a lot, well past a certain threshold of body fat that's when you start getting into these so-called metabolic disorders, where blood glucose metabolism is disrupted, leptin signaling is disrupted and there are all sorts of changes on both the brain side and the body end of things, such that they're hungry, despite the fact that the body has plenty of energy on reserve.