Paul Saladino· MD
what we know is that when you're in medical school you learn okay you can't give metformin to somebody if their creation means more than 1.4 because they'll get lactic acidosis that's not a good thing
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
what we know is that when you're in medical school you learn okay you can't give metformin to somebody if their creation means more than 1.4 because they'll get lactic acidosis that's not a good thing
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if the doses from metformin is really effective for that you are reaching the danger zone of causing lactic acidosis which has a 30 to 40 percent mortality rate
Lactic acidosis could be a problem in higher doses for some people maybe with renal insufficiency or impaired liver function.