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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Harmful downstream effects of Metaformin use — Whalespan

Content›Video›Harmful downstream effects o…

Harmful downstream effects of Metaformin use

Paul Saladino10m · 2022-04-10

Claims Made

14

Claims Supported

9

Support Rate

64%

Support rate

9 of 14 claims supported

9 supported5 partial / not

Claims from this content

13

✓Well SupportedBroken fat cells cause insulin resistance, and fixing them may lead to weight gain if dietary habits remain unchanged.✓Well SupportedMetformin use at doses approximating clinical levels shifts the NAD+/NADH ratio in the desired direction (towards NAD+).✓Well SupportedIndividuals taking metformin at doses over 1200mg/day should have their Vitamin B12 levels measured and supplement if necessary, but avoid excessive supplementation.✓Well SupportedMetformin's functional benefit is shutting down inappropriate gluconeogenesis in the liver of insulin-resistant individuals, thereby blocking hyperglycemia.Not Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✕

Metformin can cause lactic acidosis in individuals with renal insufficiency or impaired liver function.

✕Not SupportedMetformin can lead to Vitamin B12 deficiency, which can cause anemia and potentially irreversible neurological damage.

◐Partially SupportedMetformin is derived from a plant defense chemical found in French lilacs.

✓Well SupportedLactic acidosis is a rare but possible side effect of metformin.

?Limited ResearchMetformin's impact on the microbiome is complex and not well understood.

◐Partially SupportedMetformin is a life-saving drug for some individuals who do not make lifestyle changes, and its side effects are considered worth the risks in those cases.

◐Partially SupportedMetformin use is associated with a significant increase in hypospadias in males, particularly when sperm is being produced.

◐Partially SupportedNormalizing glycemia with insulin can increase testosterone levels, but metformin can then significantly drop testosterone.

?Limited ResearchMetformin may have an endocrine-disrupting effect, as indicated by its ability to drop testosterone levels.