Paul Saladino· MD
the good thing about metformin is it shuts down inappropriate gluconeogenesis at the level of the liver in people who are insulin resistant
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the good thing about metformin is it shuts down inappropriate gluconeogenesis at the level of the liver in people who are insulin resistant
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the good thing about metformin is it shuts down inappropriate gluconeogenesis at the level of the liver in people who are insulin resistant
what I showed in humans is that metformin targets hepatic glucose production or the insulin sensitivity of the liver and that's the major mechanism of action