David Sinclair· PhD
You’d want to measure it and supplement if necessary but don’t overdo it.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
You’d want to measure it and supplement if necessary but don’t overdo it.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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There’s evidence that metformin affects B12 in 20% of people taking >1200mg/d.
metformin can lead to b12 which is kind of an important b vitamin if you want to make dna and neurons and and not have horrible anemia and like potentially irreversible you know neurologic damage that's important so we have to get diabetics b12 and watch their their b12 with metformin
And then, another thing that creeps up could be vitamin B12 deficiency. So if you are...our ability to absorb vitamin B12 as we age is decreased, so maybe a sublingual form or even B12 injections in people that are older?