Metformin as a geroprotective drug
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Metformin as a geroprotective drug
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
metformin, the other diabetes drug that may delay aging
Metformin is the best studied drug that is believed prevent age-associated diseases such as Alzheimer’s and cancer
The type 2 diabetes drug metformin is finally shown to slow aging!
metformin, a cheap, widely available drug used to lower high blood sugar and potentially delay diseases of aging.
I support that study I think that it's probably the right first study in this area because as you've already said metformin we we know that it's very safe at least as far as as a drug you might consider for a study like this it's very safe
those treatments are metformin rapamycin you give it to any animal it almost delays the aging there
well I call metformin a tool from my perspective it's just a tool to show that we can target aging because I think that there will be much better drugs and combination drugs and either in the future
the bottom line is there's evidence that metformin hits every one of those hallmarks
all of a sudden we have everything we have all ages age-related disease clinical association studies would have mortality that just made metformin the perfect tool for us to push geroscience ahead
the mechanism of action the fact that metformin actually hits all the hallmarks of aging miraculously
it suggests that if if tame shows a reduction in all-cause mortality in a subset of people so old in quotes um because when i say so old meaning in five years is really what i'm saying um it would suggest biologically that there would be a benefit to starting sooner
And most people if they want to find the systems-level control of aging, they're trying to do it through metabolic health. And so people like the idea of this drug metformin, it might be a way to systematically slow aging.