Bryan Johnson· Author
1. Pharmacological Interventions: Anti-TNF therapy (anti-inflammatory), Metformin (Anti-diabetes, AMPK activation),Ketamin (antidepressant psychedelic, dissociative).
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
1. Pharmacological Interventions: Anti-TNF therapy (anti-inflammatory), Metformin (Anti-diabetes, AMPK activation),Ketamin (antidepressant psychedelic, dissociative).
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
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Interventions slowing-down Biological Aging ✅ Pharmacological Interventions: Anti-TNF therapy (anti-inflammatory), Metformin (Anti-diabetes, AMPK activation), Ketamin (antidepressant psychedelic, dissociative) ✅ Supplements: AC11 supplement (natural DNA repair booster), TruLacta (a human-milk based supplement). ✅ Lifestyle Adjustments & Surgeries: Gastric Bypass (weight reduction), smoking cessation, kidney transplant, hyperbaric oxygen therapy HBOT (large average effect, but no statistical significance) ✅ Diets: (basically a Blueprint diet) Vegan Diet, Green Mediterranean Diet, Mediterranean Diet, low fat and low carb diets.
Effect of longevity interventions on epigenetic clocks: Strongest: 1. Arthritis therapy/anti-TNFa 2. Metformin 3. HBOT 4. AC-11 5. Bypass 6. Ketamine 7. Vegan/Mediterranean