The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
First of all, there's a prescription drug Metformin, which was developed as a treatment for diabetes. And it works potently to reduce blood glucose. It has dramatic effects in lowering blood glucose. Metformin involves changes to mitochondrial action in the liver. That's its main way of depleting or reducing blood glucose. And it does so through the so-called AMPK pathway, and it increases insulin sensitivity overall.
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there's a prescription drug metformin which was developed as a treatment for diabetes and it works potently to reduce blood glucose it has dramatic effects in lowering blood glucose metformin involves changes to mitochondrial action in the liver that's its main way of depleting or reducing blood glucose and it does so through the so-called amk pathway and it increases insulin sensitivity overall
And the reaction is two fold. One is to make more mitochondria, so you get more energy a few days later, but also by inhibiting mTOR it'll improve what's called insulin signaling so that the blood sugar that's in your blood, and if you're a type two diabetic, it's too high, it gets sucked out of the bloodstream and utilized, which is why it's used to treat type two diabetes.
One thought is that the microbiome changes, but a leading school of thought that most scientists agree on is that it activates a protein complex called complex one which is involved in making energy in mitochondria. And what it does is it lowers the amount of energy that the cell has in the form of ATP, this chemical that we use for energy. And then you get mitohormesis, mitochondrial hormesis, what doesn't kill the cell makes it stronger.
AP kinase is a kinase that turns on metabolism boost mitochondrial activity amplifies the amount of mitochondria in the body and it also controls our blood sugar levels and it's one of the reasons why they researchers think metformin works is that perhaps not directly but indirectly it's turning on this pathway and allowing our bodies to be more insulin sensitive
let me tell you amp kinase is a kinase that turns on metabolism um boosts mitochondrial activity amplifies the amount of mitochondria in the body and it also controls our blood sugar levels and it's one of the reasons why they researchers think metformin uh works is that perhaps not directly but indirectly it's turning on this pathway and allowing our bodies to be more insulin sensitive