Mitochondria play a direct role in regulating inflammation by signaling inflammatory cells to turn off.

“Mitochondria play a direct role in inflammation. And they turn the inflammatory system both on-- or they at least play a role in turning the inflammatory system both on and off. I'm not going to be able to quote the exact study and author. But one paper in cell actually identified mitochondria as the key regulator in turning certain inflammatory cells off, and that when you inhibit mitochondrial function, those cells don't turn off, that mitochondrial levels of reactive oxygen species are a key signaling process to turn the inflammatory cell process off.”