David Sinclair· PhD
NAD - Sirt1 are the master regulators of circadian rhythms ⏰ 🛏 💤
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
NAD - Sirt1 are the master regulators of circadian rhythms ⏰ 🛏 💤
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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And we actually know this, that the Sirt-1 NAD cycle is part of our body's natural 24-hour clock. Sirt-1 regulates a protein called BML that controls the genes that tell us whether it's night or day, should we be hungry or not? Whether we have jet lag or not.
in doing so, what they do is they turn on a particular gene called BMAL, which is part of the clock, not the Horvath clock, but the daily clock, the circadian rhythm clock. And those genes tell the liver to calm down, it tells the brain to calm down, and in the morning, tells everything to wake up again.
even at the molecular level, we understand that SIRT1 and NAD play a fundamental role in controlling your wake-sleep cycle. SIRT1 and NAD are going up in the morning, coming down later in the day, getting your body ready for sleep
And we actually know this that the SO1 NAD cycle is part of our body's natural 24-hour clock.