David Sinclair· PhD
Over the course of aging, NAD+ levels decrease in various tissues, including skeletal muscle, where clinical evidence underscores age-related NAD+ deficiency
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Over the course of aging, NAD+ levels decrease in various tissues, including skeletal muscle, where clinical evidence underscores age-related NAD+ deficiency
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Healthy aging and muscle function are positively associated with NAD+ abundance in humans
The encouraging part is that older adults who are physically active maintain muscle NAD⁺ levels comparable to younger individuals.