David Sinclair· PhD
Joe Bass @NorthwesternU shows the boosting of NAD in old mice restores a youthful clock.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Joe Bass @NorthwesternU shows the boosting of NAD in old mice restores a youthful clock.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Also NAD controls circadian clocks and AMPK, a target of metf controls NAD.
Ups & downs in NAD+ over 24 h dictates our body's clock & sleep
we know nad goes up and down it changes with age
How acute sleep loss affects NAD
Does poor sleep reduce NAD?
It's a combination. It will be going up and down with circadian rhythms, mostly, but you can adjust it within the...
What's interesting about this is that NAD isn't being driven by the clock, the clock is being driven by NAD.