The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it's very important that you not get fast large amplitude increases in dopamine that are not preceded by effort yeah you methamphetamine will give you a large amplitude um you know fast increase in dopamine but it the there's zero effort involved except to procure it and it sinks you into a post dopaminergic Peak trough at afterwards that um will have you um hanging on for for the will to live
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
it sinks you into a post dopaminergic Peak trough at afterwards that um will have you uh hanging on for for the will to live um so what comes up goes down and it often goes down further than it went up when we're talking about dope
those big fast inflections in dopamine very quickly lead to smaller and smaller peaks in dopamine from the same behavior or substance and then the trough of low that comes after is just immense.