The ability to sleep without supplements after a missed night suggests that neural circuits for sleep have undergone plasticity and function independently of supplementation.

“what this means is that many of these things magnesiums in particular can build up in the body and brain in a way that can be beneficial and what probably explains the fact that you can still sleep if you miss a night of taking them is that the neural circuits that are involved in turning off thinking or in not thinking and falling asleep those neural circuits undergo what's called plasticity in other words if you get better at falling and staying asleep over time even if you got better at that through the Assistance or with the assistance of some supplement or combination of supplements well then those circuits are still going to function just fine even in the absence of”