NMN and NR supplementation can deplete methyl groups, potentially requiring monitoring of B vitamin status, methylation status, and homocysteine levels, and possibly supplementation with methylfolate or betaine. — Whalespan
NMN and NR supplementation can deplete methyl groups, potentially requiring monitoring of B vitamin status, methylation status, and homocysteine levels, and possibly supplementation with methylfolate or betaine.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“well nmn and nr are going to deplete your methyl groups so that's actually problematic looping back to the mt shift r thing that we talked about you know if you're if you really believe that you can have longevity benefits and the whole nad thing i think is a fascinating conversation i'll just comment on it briefly i think that there's something there but if you really believe that there's substantial evidence that nr nicotinamide riboside or nicotinamide mononucleotide are going to give you longevity benefits then by all means take them but understand that like you probably want to check your b vitamin status and understand your methylation status and your homocysteine you might want to take methylfolate you might want to take betaine which is trimethylglycine because they're going to deplete those things”