David Sinclair· PhD
Nicotinamide riboside (NR) speeds up wound healing in diabetic mice, consistent with our work on the related molecule, NMN, where we saw the restoration of blood vessel growth in older mice https://t.co/kdvcyQVUS5
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Nicotinamide riboside (NR) speeds up wound healing in diabetic mice, consistent with our work on the related molecule, NMN, where we saw the restoration of blood vessel growth in older mice https://t.co/kdvcyQVUS5
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Consistent with this, in 2018 we found that raising NAD+ with NMN boosts activity of SIRT1 & improves endurance by stimulating the growth of blood vessels and blood flow in muscle.
In mice, NMN is found to preserve the BBB by activating the NAD-dependent enzyme linked to longevity, SIRT1
In 2018-19, we and Zoltan Ungvari’s lab showed that mice treated with an NAD booster (NMN) had better blood flow in muscle & brain, with greater endurance & cognition
Here’s the study with Prof. Ungvari and team in 2019 of cerebral vascular function and improved memory in mice
This is our 🐁 study from 2018 showing improved vascular function and endurance in muscle of mice treated with NMN
Not cause <-> effect but our 2018 Cell paper showing enhanced blood flow & endurance w NMN via SIRT1 fits 🏃♀️ @CellCellPress 🏃♂️@harvardmed: https://t.co/bocsGCxFUk
For example, we could reverse the age of the microvasculature (cf. #COVID) and muscle within 4 weeks just by letting them drink some NMN.
We found not only does NMN and SIRT1 activity maintain the youthfulness and ability to grow new blood vessels in the mouse as muscle, but we collaborated with Zoltan Ungvari at the University of Oklahoma to show that mice, even in their brains, benefit from NMN by building new blood vessels. And those elderly mice not just had better blood flow, but could think and remember things better.
Well, almost undoubtedly, that's what was going on in those mice, because we could block the effect. We could actually downregulate the SIRT1 specifically in those endothelial cells that line blood vessels, and then the benefit of NMN went away.
One of the benefits that we might see is also improved blood flow and that might be helpful for vascular dementia because, as I'm sure you know, we've shown that NMN and others have shown for NR that it also helps with blood flow and actually mimic exercise and regrow the vascular system.