The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Or by taking NMN which, and here there's been some, let's just say, debate as to whether or not taking NMN actually leads to increases in NAD within our cells, whether or not it can get into our cells, whether or not it's converted into NAD, and so on and so on.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Our latest collaborative paper on how the microbiome processes NMN for absorption @LindsayWu_UNSW and team 👏 [@agingdoc1: Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions Lynn-Jee Kim, @LindsayWu_UNSW & colleagues https://t.co/kLIdOr1ozg]
my opinion is that the microbiome removes a lot of the nicotinamide from nmn and event are before it's taken up by the gun there are some studies that I've seen and I'm yet available that trace the movement of these molecules through an animal
but you know my base assumption is that often the obvious is true and here the obvious would be you know the physiological system just isn't that impacted by this particular type of oral supplement
but i think this is how i'd fundamentally think about them is that they're niacin prodrugs your lab has done some some of the flux work on this correct what what are some of the most interesting things you've learned about how nr and how nmn when given orally end up in different tissues and what the effect is in the liver versus the muscle versus the plasma yeah i i think the main thing you see is that you know these are converted to niacin they will raise niacin particularly niacin heading to the liver out of the gastrointestinal tract so in the what we call the portal circulation that connects you know your intestine to the liver uh very effectively and that you know other than that their effect on like boosting their own circulating levels is somewhere between subtle and vanishing i'm still not sure which of those two it is but i i think they certainly remain in the bloodstream much less abundant than nicotinamide which is the thing the liver is normally producing to feed nad precursor to the tissues of the body and so there there's from what we have seen no clear route for oral nr or oral nmn to produce circulating levels of nro or nmn that are high enough to compete at least at a standard concentration level with nicotinamide the physiological precursor as a way of feeding nad precursors to tissues so basically at some level they don't change what's happening and what most your tissues are seeing that much if our measurements are correct
yeah i mean it could be that you know there are local effects of nr or nmn on like the intestine that are really important it could be that their availability impacts the microbiome in important ways the microbiome can have big effects on health uh it could be that even though the amounts of like nr that may reach the liver or even lower amounts that may reach you know the heart or something are really small that there's a subset of cells there that are really in our preferring because maybe they're really deficient in using nicotinamide and maybe getting even small amounts of nr to those cells is meaningful so i think these are all possibilities that we're very much open to
And there's a lot of mechanisms involved in that. But like, you know, I'm wondering if some of the effects you were talking about also may be indirect from raising it in the blood perhaps, maybe that's signaling each other