David Sinclair· PhD
what’s needed is a human head-to-head study of blood and tissue NAD levels.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
what’s needed is a human head-to-head study of blood and tissue NAD levels.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
there's some of course pilot clinical studies showing that yes you can take for example in the coton right right beside and it does seem to increase nad levels in plasma in a dose-dependent manner
if you're treating somebody with nr or nmn and you're not increasing nad levels in the blood or in your target tissue that should tell you something important i would think
so you know if you're treating somebody with nr or nmn and you're not increasing nad levels in the blood or in your target tissue that should tell you something important i would think
it should be trivial to determine whether or not you have boosted nad levels right if you treat somebody with an nad precursor we know how to measure nad that's not hard
It would make sense because we've done a lot of this in mice and now in humans, and that there's a threshold that you need to cross, you need to take a certain amount to get over probably the body's clearance mechanisms and then you get up to a level that plateaus after about nine days.
Can you please tell people the question I know that's in their minds, which is, why can't I just supplement with NAD? Why do I have to take this precursor?