Paul Saladino· MD
we know that wheat gluten of course will increase the permeability of the gut even in a normal person yes
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we know that wheat gluten of course will increase the permeability of the gut even in a normal person yes
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I believe there's also good evidence that many humans will release zonulin, if not all humans, when they're exposed to gluten, even if they are not celiac. This is the non-celiac gluten sensitivity.
For those with celiac disease (or true non-celiac gluten sensitivity), gluten exposure can increase intestinal permeability, trigger immune activation, and drive GI symptoms.
it is thought that you know so people with celiac disease it's thought that gliadin is the major problem for them because of this this mechanism
so people with celiac disease it's thought that gliadin is the major problem for them because of this this mechanism the release of zonulin and therefore disassembly of the tight junctions which actually stay disassembled for quite a long time and allow lps to then go into circulation and do all the things that we just talked about with people that don't have celiac it's thought that it might be a more transient opening and closing