AgRP neurons controlling hunger are primarily calorie-specific and can be inhibited by equal caloric amounts of sugar, fat, or protein.

“most of the circuits that are controlling hunger are primarily calorie specific so they they can like for example an arrp neuron I can put sugar fat or protein into the stomach of a mouse and to an equal extent inhibit an agrp as long as they have equal calories really yeah so a little drop of olive oil into the belly that has of an animal that has um let's drop let's say a little bit more let's say um 120 calories of olive oil is equipotent to 120 calories of chicken breast at the level of”