Andrew Huberman· PhD
and then what we see is that in that food deprive after one day of food dep deprivation for mice um you can see this shift in the balance between the positive veilance um encoding projection neurons and the negative bance and coating projection neurons and a at Baseline fear trumps all the negative projection neurons you know can silence the reward projection ones which makes sense if I need to run away from this Predator you know I can't I can't worry about eating this food right now but if I'm in a near starvation like state which for my they have very high metabolism so one day without food is a really big deal deal um they only last a few days so um at this point they are kicking into survival mode where actually getting food becomes the the greater need and you'll see animals you know hunting in ways they normally wouldn't hunt when when they're really desperate and so this mode of of food deprivation shifts things so that the reward um pathway actually has stronger power to to influence and silence the uh fear pathway than before