Supplementing with betaine HCL and pepsin during meals may benefit individuals with food allergies, mood issues, or autoimmune conditions.

“By changing the acidity, you also changed the way that the gut communicates with the brain through the mechanisms we talked about before. And there are a growing number of people embracing these practices of taking HCL. It's often combined with other things, it's usually combined with an enzyme and that enzyme is pepsin? So most of these supplements come in the form betaine HCL pepsin and while they're not a cure-all, and certainly don't want to suggest that they're a cure-all, many people that have a hard time adjusting the pH of their gut and have a hard time adjusting the microbiota of their gut in the appropriate ways have benefited from taking these betaine HCL pepsin tablets or capsules during meals.”