The modern American diet, with constant exposure to linoleic acid-containing fats, leads to a continuous supply of HNE and its associated toxins.

“4-h e is an oxidative product of linoleic acid metabolism and they were looking at ambulatory symptomatic heart failure patients”

“the key thing to note the key thing to be aware of is that linoleic acid is so unstable that it auto oxidizes even if it's just sitting in your cells right you don't have to have it sitting in a jar for it to oxidize if you eat enough of it it will build up in your cells and it will oxidize there right it turns it's going to turn into hne this is shown in the literature in adipocytes”

“if you eat more than elenic acid you get more of the land gas in your cell membranes okay now let me know if you have more than of gas in your cell membranes you get more hiv okay if you have more h and even more oxidative stress okay if you have more hiv you have more oxidized ldl okay if you have more hne you have more disease fat cells”

“where does linoleic acid come from in the human body it comes from what we eat we don't make any linoleic acid in the human body that's why it's considered quote essential but I think that the levels needed for optimal human physiology are much lower than what we consider today”

“the formation of toxic Alpha Beta unsaturated four hydroxyaldehydes like hne in thermally oxidized fatty acid methyl Esters”

“even some of the toxins that were discussing hne which is probably the best studied oxidative product of linoleic acid has signaling rules in the body right it's you know a fundamental part of our metabolism but it's supposed to be there in a certain quantity and we have you know by dumping excess linoleic acid into our bodies we seem to have increased the amount of this Toxin and everywhere you look through chronic disease every single chronic disease this toxin is thought to play a role”

“now hne is a great marker of the negative health effects of linoleic acid because it's only produced from linoleic acid right there are other markers that they use that can be produced from omega-6 or omega-3 fats and you know different types of um you know different types of markers this one is specific to linoleic acid”

“but unfortunately in the context of the modern American diet you can't stop it because you're constantly eating it as you mentioned earlier right every meal you're exposed to these fats and they're breaking down into these toxins in your body”

“the source for hne in the human body is linoleic acid that's where it comes from it's not coming from anywhere else the only other place from omega-6 fats so it can also be made from arachidonic Acid which typically you only have a tiny amount of in the body”

“so hne is uh for hydroxy known and all and I will not say that again in this podcast um hne is when you oxidize a linoleic acid molecule it breaks in half and that's half of it right hna”

“what breaks fat cells hne where does that come from linoleic acid so there's a real clear path and that's an oversimplification but that is true and we know that hne breaks fat cells”

“blood levels not so good and we'll talk about why because primarily because the linoleic acid breaks down and so in the blood it can be broken down so if you see lower levels of linoleic acid in the blood it can mean that it's just breaking down into hne which is the bad byproduct of linoleic acid that causes many problems for humans so blood levels of linoleic acid not a good indicator”

“if you see lower levels of linolic acid in the blood it can mean that it's just breaking down into h& which is the bad byproduct of linolic acid that causes many problems for humans”