Paul Saladino· MD
it's it any of the liquid fats in people that have underlying gut dysbiosis or the wrong type of bacteria and their gut thus gram-negative overgrowth could potentially increased postprandial and the toxin in the blood
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it's it any of the liquid fats in people that have underlying gut dysbiosis or the wrong type of bacteria and their gut thus gram-negative overgrowth could potentially increased postprandial and the toxin in the blood
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in the setting of a healthy gut flora saturated fat is not going to cause endotoxemia in any way shape or form so it's dependent on the gut flora of the individual and if you have dysbiosis sometimes a lower fat diet is better in the short term while that is being cleaned up again i've talked about that in more detail in the past with tommy wood but there is no evidence that saturated fat from animals is going to cause inflammation or endotoxemia in someone with a quote healthy microbiome
but does it happen in people who don't have gut issues or don't have dysbiosis it really doesn't there's not a lot of good evidence that saturated fat is harmful for the gut in any way shape or form or induces postprandial endotoxemia in a healthy population these are generally studied in unhealthy populations that already have dysregulated guts