The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The most famous example of a non-protein amino acid causing issues in humans is cannabine a substance found in alfalfa sprouts which is well known and well studied and well documented to cause a clear lupus-like syndrome in humans
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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first reported in a volunteer who developed lupus-like autoimmunity while ingesting alfalfa seed for a hypercholesterolemia study
if you get too many alfalfa sprouts there's pretty good documentation in the medical literature of this lupus-like autoimmune syndrome
there are non-protein amino acids in alfalfa which do lead to a lupus-like syndrome when consumed in excess in humans
phytoelectins in some food plants alfalfa not a good thing to eat i've talked about that in a previous podcast there are non-protein amino acids in alfalfa which do lead to a lupus-like syndrome when consumed in excess in humans