Andrew Huberman· PhD
And then you have like let's say 50 people here, 50 people here. And then you ask, did the ketogenic diet improve mental health or did it reduce inflammation or right, did it do that? And and then often in RCTs for dietary interventions or drugs, what you find is not really, maybe a little bit, right? And then if this the study was adequately powered and there's like an 8% you know shift in your primary outcome then it becomes p less than 0.05 the the p value the statistically the statistical uh you know value here becomes significant and now you say the ketogenic diet is effective for this or the ketogenic diet does not work you know for for eggs. This and this is I think highly misleading because when you peel the surface of any randomized clinical trial, you find that there are people who were like amazing responders. Like there are people whose lives was changed truly. Uh and then there are people who didn't change anything. And then there are also people who got worse. Uh and then you average everyone. You squish everyone into this average. And then the RCT is is a statistical test of averages. Nobody