The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so so um so among the severely obese people have sort of genetically inherited severe obesity from childhood uh something on the earth 10% have mutations in this pathway so it's very clear that this uh that this this pathway is involved in body weight regulation in humans
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
we know from Human genetics that the these um that among severely obese people mutations in this pathway agrp palc neurons and their direct Downstream targets are quite common
among those people something on the order of 10% have mutations