Obesity, through inflammation and associated growth factors like insulin and IGF-1, is a significant environmental trigger for approximately 25-27 types of cancer, including colorectal and potentially lung cancer.

“obesity is clearly driving cancer not all cancers but many cancers about two-thirds of cancers have a very strong tie to obesity I think if you look under the hood of that you'll realize it's probably not the excess fat per se or the adiposity that's driving cancer and rather it's the growth factors that are doing it so obesity comes with more inflammation comes with more growth factors such as insulin and igf and it seems more likely that those are the things that are actually leading the increase uh in cancer”

“I think we have a pretty good idea first of all I don't think it's the excess at aity right like I don't I don't think it's the extra two pounds I have on my waist that I wish I didn't have for vanity purposes um it is the environment of growth factors that comes with obesity namely the hyperinsulinemia but also the chronically elevated igf and things of that nature and it is the inflammatory environment that comes Rife with obesity”