Paul Saladino· MD
they gave mice linoleic acid they saw them get fat and they saw anandamide and endogenous and endocannabinoids go up
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
they gave mice linoleic acid they saw them get fat and they saw anandamide and endogenous and endocannabinoids go up
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And what they found was that increasing linoleic acid from 1 to 8% elevated arachidonic acid phospholipids in the liver and erythrocytes, tripled 2-AG and 1-AG and AEA, which is anandamide, associated with increased food intake, feed efficiency, and adiposity in mice.
which led to increased feed efficiency meaning that mice were incorporating more calories into their bodies essentially basil metabolic rate appeared to be lowering which is something that I'll talk about in a moment with regard to thyroid hormones in connection with linolic acid and they had adiposity