Seed oils are sabotaging your satiety

PS

Paul Saladino7m · 2022-09-15

Claims Made

13

Claims Supported

12

Support Rate

92%

Support rate

12 of 13 claims supported

12 supported1 partial / not

Claims from this content

12

Well SupportedLinoleic acid in seed oils increases anandamide and 2-AG in the brain, which binds to CB1 receptors and induces hunger.Well SupportedA diet higher in stearic acid and lower in linoleic acid promotes healthy leanness.Well SupportedThe drug rimonabant, a CB1 receptor antagonist, was effective at reversing obesity and diabetes by affecting the cannabinoid receptor.Partially SupportedMice fed linoleic acid showed increased levels of anandamide and other endocannabinoids.Partially Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Linoleic acid intake raises tissue arachidonic acid, increasing prostaglandin production and stimulating pathways implicated in adipogenesis, leading to more fat cells.

Not SupportedRimonabant was discontinued due to concerns about suicide and depression, suggesting humans need CB1 receptor signaling.

Partially SupportedDietary linoleic acid increases liver arachidonic acid phospholipids and endogenous cannabinoids in mice.

Partially SupportedLinoleic acid intake may lead to more fat cells in humans.

Partially SupportedThe relative intake of omega-6 to omega-3 fatty acids is an emerging factor in adipose tissue development.

Partially SupportedHigh dietary fat intake may contribute to adipose tissue development by influencing adipocyte differentiation and proliferation.

Partially SupportedHigh dietary fat intake during early postnatal development stimulates adipocyte hypertrophy and hyperplasia, potentially creating susceptibility into adulthood.

Partially SupportedRimonabant resulted in an average weight loss of 4.7 to 5.4 kilograms over one year in clinical trials for obesity management.