Paul Saladino· MD
so basically what they're saying here is mice were fed diets containing 1 percent of energy from linoleic acid 8 percent of energy from linoleic acid and 8 percent of energy from linoleic acid plus 1 percent from EPA which is an omega-3 fatty acid with some dough costs a hexanoic acid that I talked those were shown on the first slide those are omega-3 fatty acids so the conclusions were that increasing linoleic acid from 1% which is probably at least in humans again this is a mouse model but at least in humans 1% linoleic acid is probably more incest really consistent to an 8 percent level elevated these arachidonic enriched phospholipids they're saying that when you give these mice linoleic acid it's a precursor for a raft donek acid and that could induce endocannabinoid hyperactivity and promote obesity so that's what it did when you jump from one to eight this is akin to what's happening in the standard American diet and it did that arachidonic and rich phospholipids in liver and Ruth recites it tripled to AG which is one of these endogenous cannabinoids and AEA and the Amanda mine with increased food intake feed efficiency and adiposity in mice