Controversial Thoughts! 6/29/20, Birthday Edition

PS

Paul Saladino26m · 2020-06-29

Claims Made

46

Claims Supported

36

Support Rate

78%

Support rate

36 of 46 claims supported

36 supported10 partial / not

Claims from this content

33

Well SupportedStearic acid ingestion increases circulating C18 triglycerides and activates mitochondrial beta-oxidation.Well SupportedStearic acid, enriched in animal foods and absent in plant foods, signals the body to burn fat, and its deprivation leads to fragmented mitochondria.Well SupportedDietary stearic acid regulates mitochondrial function in humans, with stearic acid deprivation leading to decreased mitochondrial activation and fragmentation.Well SupportedGrass-fed, grass-finished ruminant meat contains less than 2% linoleic acid.Well Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Dietary linoleic acid elevates appetite-stimulating endocannabinoids anandamide and 2-AG, and induces obesity in mice.

Well SupportedThe amount of fat consumed affects the endocannabinoid pathway, specifically influenced by omega-3 and omega-6 fat components.

Well SupportedDietary stearic acid reduced visceral adipose tissue and was associated with reduced metastatic tumor burden in athymic nude mice.

Well SupportedStearic acid enrichment in the diet protected against type 2 diabetes progression in mice.

Partially SupportedSaturated fat in red meat, particularly grass-fed meat, should not be feared.

Partially SupportedAs fat cells expand, they release 'lipokines' which signal to the body regarding insulin sensitivity or resistance.

Partially SupportedLinoleic acid is detrimental to rats and likely to humans.

Not SupportedThere is no perceived benefit to consuming large amounts of linoleic acid, and efforts should be made to eliminate it.

Partially SupportedWestern humans consume 12-14% linoleic acid, and lab animals consuming over 5-6% linoleic acid experience rapid health decline.

Partially SupportedTallow is preferred as a primary fat source due to its higher stearic acid content, which is beneficial for visceral fat and whole-body insulin sensitivity.

Partially SupportedPalmitoleic acid signals the body to remain insulin sensitive.

Partially SupportedVisceral fat's insulin sensitivity is determined by lipokine signals originating from that fat.

Not SupportedA low-fat vegan diet led to mitochondrial fragmentation.

Partially SupportedExcessive intake of polyunsaturated fats, especially linoleic acid, may signal visceral adipose tissue to grow.

Partially SupportedA low-fat vegan diet for two days led to fragmented mitochondria and reduced acyl carnitine usage, indicating impaired fat oxidation.

Partially SupportedLinoleic acid is essential for the development of experimentally induced alcoholic liver injury in a rat model.

Partially SupportedStearic acid causes increased programmed cell death in pre-adipocytes, leading to a loss of visceral adipose tissue cells.

Partially SupportedIndividuals who neglect to eat important molecules found in red meat, such as stearic acid, may have higher visceral adipose tissue compared to those who consume it.

Partially SupportedPeople not eating animal foods are hypothesized to have more visceral fat and be more insulin resistant.

Partially SupportedPaul Saladino plans to conduct experiments to decrease linoleic acid intake and observe its effects on his body composition.

Partially SupportedVisceral adipose tissue is an indicator of metabolic health, and not consuming ruminant meat and fat (rich in stearic acid) may be associated with more visceral fat.

Partially SupportedPalmitoleic acid stimulates insulin action and suppresses fatty liver.

Partially SupportedDiets high in linoleic acid from vegetable oils and animals fed corn/soy may not protect against alcoholic liver injury.

Partially SupportedThe correlation between new COVID-19 cases and hospitalizations or deaths has broken down, with deaths declining.

Partially SupportedVisceral fat is related to metastasis and decreased survival in breast cancer models.

Not SupportedExcess linoleic acid is detrimental in mouse studies, leading to obesity and metabolic problems.

Not SupportedIncreasing dietary linoleic acid from 1% to 8% of energy in mice promotes obesity.

Partially SupportedCorn oil and safflower oil can make rats fat and increase their visceral adipose tissue.

Partially SupportedLinoleic acid can cause fatty liver and obesity in rats and potentially in humans.