Dietary linoleic acid elevates appetite-stimulating endocannabinoids anandamide and 2-AG, and induces obesity in mice.

“effective diets enriched in linoleic acid and its peroxidation products on brain fatty acids oxy lipids and aldehydes and mice”

“these scientists did this really cool study where they took these poor little mice and they gave them either one percent of energy as linoleic acid eight percent of energy is linoleic acid or eight percent of energy is linoleic acid plus one percent of energy as epa plus dha and what they found was a clear response where linoleic well linoleic acid induces obesity in these mice”

“so uh uh there we go this is about as clear a pathway as exists in the literature it has been reproduced multiple times that I'm aware of um ever since this was done some papers who were intentionally trying to reproduce this effect and some people who were working in parallel but still came to the same conclusion it appears that in animal models if you want to reliably induce insulin resistance and obesity you use linoleic acid yay and then ramonovan blocks this effect you know and this you know there's a whole range of papers looking at the effects”

“in summary dietary linolic acid increased tissue or aconic acid subsequently elevated 2 AG plus 1 Ag and AA which is anandamide resulting in the development of the diet induced obesity”

“increasing the acid from 1 to 8% elevated arachadonic acid phospholipids in the liver and erthrocytes it tripled 2 Ag and one Ag and aea Associated with increased food intake feed efficiency and adiposity in mice”