SSRIs inhibit the activity of the serotonin transporter, slowing serotonin deactivation and increasing extracellular serotonin.

“So SSRIs don't increase the total amount of serotonin in the brain. They change how effective the serotonin that's already in the brain is at changing the activity of neurons, okay? So they don't increase serotonin, they increase the efficacy or the function of serotonin in the way that I just described.”

“What does that mean? Well, serotonin is a neurotransmitter. It's actually a neuromodulator that's released into the synapse, and then the SSRI, the selective serotonin re-uptake inhibitor allows more of that serotonin to sit within the synapse for longer, it's a re-uptake inhibitor, it prevents re-uptake by the presynaptic neuron. and that serotonin therefore can park in or dock in the receptors, as it's called, of the postsynaptic neuron in greater numbers, and have a greater impact on that postsynaptic neuron.”

“the official mechanism of action for which for which these drugs through which these drugs got approved is that it inhibits the activity of the serotonin transporter which means the serotonin deactivation is slowed down right and you get more extra cellular serotonin”

“because those already actually you know the official mechanism of action for which for which these drugs through which these drugs got approved is that it inhibits the activity of the serotonin transporter which means the serotonin deactivation is slowed down right and you get more extra cellular serotonin to wreak all kinds of Health George is having to move around okay”